Kv1.3 - Kv1.5 - ion channels - macrophage - patch-clamp

Diego Alberto Peraza Pérez

Department of Biochemistry and Molecular Biology and Physiology Ion Channels and Vascular Pathophysiology Institute of Biomedicine and Molecular Genetics (IBGM) UVa-CSIC
My research career

I graduated with a degree in Health Biology from the University of Alcalá (2014). Subsequently, I obtained a Master's degree in Pharmacological Research (2015) and a PhD in Molecular Biosciences (2020) from the Autonomous University of Madrid. Then, I moved to the University of Valladolid (UVa) where I started my postdoctoral stage with a research contract from the Junta de Castilla y León for two years (2022) at the Institute of Biomedicine and Molecular Genetics (IBGM) UVa-CSIC. During this period, I was Visiting Researcher at the University of Colorado (USA) for a three-month postdoctoral stay (2022). Since my research career has been developed in university environments, I have had the opportunity to carry out teaching work, especially during my current stage as a postdoctoral researcher. Currently, I am still at the IBGM UVa-CSIC with a new two-year contract as a Juan de la Cierva-Formación postdoctoral researcher (2024).

My research

I study the contribution of the Kv1.3 ion channel to the macrophage inflammatory response associated with cardiovascular and metabolic diseases. I work in the ion channels and vascular pathophysiology laboratory where we elucidate the molecular mechanisms that determine vascular smooth muscle cell (VSMC) dedifferentiation. My research project consists of studying VSMC immunoregulation mediated by immune cells that play a relevant role in vascular pathology, such as macrophages and lymphocytes. I am particularly interested in studying the involvement of macrophage Kv1.3 channels in the crosstalk between VSMCs and macrophages.

My vision is to be a reference in the study of the Kv1.3 ion channel in macrophages not only at the level of cellular mechanisms but also in the functional contribution of the Kv1.3 channel in the biological functions of macrophages with therapeutic application in cardiovascular and metabolic diseases.